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Hyaluronic acid targeted oncolytic virus therapy. Oncolytic adnovirus ICOVIR17 infects glioblastoma cells and induces expression of PH20 hyaluronidase. PH20 is secreted and degrades hyaluronic acid (HA) in the extracellular matrix. Immunogenic cell death triggered by ICOVIR17 and HA degradation result in activation of T cells and macrophages in the tumor microenvironment.
