PI3K-AKT |
AKT3, TSC2, PTEN, mTOR, PIK3CA, RPTOR, TSC1, TCS2, RICOTR, PI3K3R2, PI3K3CB, INPP4B, STK11, PPP2R1A, PIK3R1, AKT2, RHEB, PDK1, AKT1 |
RAS/MAPK |
KRAS, MAP2K1, NF1, NF2 |
Wnt/β-catenin |
AXIN1, AXIN2, RNF43, WNT7B, WNT108, AMER1, CHD4, TCF7L2, WNT10A |
Cell cycle |
TP53, TERT, CTNNB1, ATM, APC, CDK4, CCND1, CCND3, CCND2, CDKN2A, RB1, CCNE1, CDK6, CDK8, CCKN2A/B, CDKN1B CDKN2B |
DNA repair |
ATR, ATM, BACA1, BRCA2, MLH1, MSH2, MSH6, FANCA, BRIP1, BAP1, CHEK2, ERCC2, FANCA/D2/E/L, MUTYH, NBN, PMS2, RAD50/51B, WRN |
Transcriptome |
IGF1R, RET, ERBB2, EGFR, KIT, PDGFRA, KDR, ERBB4, FLT4, PDGFRB, MET, FLT3, ERBB3 |
Growth factor receptors |
MYC, SOX2, KDM6A, SMARCA4, RUNX1, MYCN, EZH2, NKX2, KMT2D, SMARCB1, DNMT3A, MYCL1, SOX10, ARID2, ASXL1, DNMT3A, EP300, KMT2C, KMT2D, NSD3, PBRM1, SMARCB1, SETD2, BAP1, IDH1, IDH2 |