Table 3.
The genes fusing with FGFR1-4 in the dataset (31 cases)
| Gene partner, chromosome location | Specific fusion (n) | Tumor types (n) |
|---|---|---|
| SH3GLB1, chromosome 1: 87191379 | FGFR2-SH3GLB1 (2) | Liver cancer (2) |
| BICC1, chromosome 10: 60426432 | FGFR2-BICC1 (1) | Liver cancer (1) |
| TACC2, chromosome 10: 123996320/123991849 | FGFR2-TACC2 (2) | Renal cancer (1), gastric cancer (1) |
| TACC3, chromosome 4: 1743533/1737371/1739077/1740504/1739733 | FGFR3-TACC3 (5) | CUP (3), lung cancer (1), brain cancer (1) |
| CAT, chromosome 11: 34463828 | FGFR2-CAT (1) | Lung cancer (1) |
| TDRD1, chromosome 10: 115939394 | FGFR2-TDRD1 (1) | Liver cancer (1) |
| CCDC158, chromosome 4: 77292242 | FGFR2-CCDC158 (1) | CUP (1) |
| CIT, chromosome 12: 120186475 | FGFR2-CIT (1) | Liver cancer (1) |
| TXLNB, chromosome 6: 139595138 | FGFR2-TXLNB (1) | Liver cancer (1) |
| NKD2, chromosome 5: 1011532 | FGFR2-NKD2 (1) | Sarcoma (1) |
| CUX2, chromosome 12: 111570060 | FGFR2-CUX2 (1) | Sarcoma (1) |
| HK1, chromosome 10: 71051284 | FGFR2-HK1 (1) | Liver cancer (1) |
| EIF4ENIF1, chromosome 22: 31884504 | FGFR2-EIF4ENIF1 (1) | CUP (1) |
| DOCK1, chromosome 10: 129093385 | FGFR2-DOCK1 (1) | Gastric cancer (1) |
| TACC1, chromosome 8: 38683244 | FGFR2-TACC1 (1) | Biliary tract cancer (1) |
| TP63, chromosome 3: 189457592 | FGFR2-TP63 (1) | Lung cancer (1) |
| PAH, chromosome 12: 103300452 | FGFR2-PAH (1) | Liver cancer (1) |
| TRIM8, chromosome 10: 104408969 | FGFR2-TRIM8 (1) | CUP (1) |
| ERC1, chromosome 12: 1241041 | FGFR2-ERC1 (1) | Biliary tract cancer (1) |
| CASP7, chromosome 10: 115441363 | FGFR2-CASP7 (1) | Liver cancer (1) |
| LGSN, chromosome 6: 64006372 | FGFR2-LGSN (1) | Liver cancer (1) |
| ZNF346, chromosome 5: 176472292 | ZNF346-FGFR4 (1) | Lung cancer (1) |
| UVSSA, chromosome 4: 1377083 | UVSSA-FGFR3 (1) | Lung cancer (1) |
| LINC01580, chromosome 15: 94446896 | LINC01580-FGFR2 (1) | CUP (1) |
| NRAP, chromosome 10: 115383150 | FGFR2-NRAP (1) | CUP (1) |
Notes: CUP, carcinoma of unknown primary.