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Proteins with either modular domains (A) or intrinsically disordered regions (IDRs) (B) are able to form liquid-like phase-separated condensates. (A) Protein can form phase-separated condensates through the modular domains. One of the examples is SH3 domain (a typical modular domain) that interacts with proline rich motifs (PRMs). (B) Protein with intrinsically disordered domains (IDRs) can form phase-separated condensates through either N-terminal or C-terminal IDRs.
