Figure 2.

A summary of organization in the regions of promoters and super-enhancers (SEs) containing all the component proteins mediating gene transcription. The figure presents an overall picture of how the transcription factors, co-activators, mediators, and RNA Pol II work together to constitute a well-functional transcription apparatus. In the promoter region, OCT4 and GCN4 are representative transcription factors that interact with the preinitiation complex (PIC), Mediators, and RNA polymerase II (Pol II) to mediate gene transcription. The CTD domain of Pol II interacts with TAF15 and CDK9, a transcription elongation factor. In the super-enhancer region, the enhancer-binding transcription factors interact with MED1, BRD4, and p300 to further form a big transcription apparatus encompassing the promoter and enhancer regions. TAZ participates around the enhancer region through bridging by TEAD4 to MED1.