Table 3.
Reverse genetic B cell malignancy transplantation assays using primary lymphomas.
| Publication | Donor lymphoma genotype | Recepient | Donor cell type | Genes delivered | Malignancy type |
|---|---|---|---|---|---|
| Schmitt CA et al. (123) | Eμ-Myc | syngeneic | primary B lymphoma | Bcl2 ORF virus | B lymphoma |
| Schmitt CA et al. (124) | Eμ-Myc | syngeneic | primary B lymphoma | Bcl2 ORF virus | B lymphoma |
| Schmitt CA et al. (125) | Eμ-Myc, Eμ-Myc;Trp53+/-, Eμ-Myc;p19ARF+/- & Eμ-Myc;Cdkn2a/p19 ARF+/- | syngeneic | primary B lymphoma & fetal liver derived HSPCs | Bcl2, Casp9 dominant negative Cdkn2a & p19ARF ORF viruses | B lymphoma |
| Schmitt CA et al. (135) | Eμ-Myc or Eμ-Myc;Trp53+/- | syngeneic | primary B lymphoma & fetal liver derived HSPCs | Bcl2 & Casp9 dominant negative ORF viruses | B lymphoma |
| Refaeli Y et al. (126) | Eμ-Myc;BCRHEL & Eμ-Myc;BCRHEL;sHEL | syngeneic | primary B lymphoma | Cd79a (lgα) & Cd79b (lgβ) shRNA virus | B lymphoma |
| Young RM et al. (127) | Eμ-Myc;BCRHEL & Eμ-Myc;BCRHEL;sHEL | syngeneic | primary B lymphoma | Syk shRNA virus | B lymphoma |
| Meacham CE et al. (136) | Eμ-Myc;p19ARF-/- | syngeneic | primary B lymphoma | 1000 gene shRNA virus library | B lymphoma |
| Mu P et al. (137) | Eμ-Myc;miR-17~92ff/ff;Rosa26-Cre-ER | athymic nude mice | primary B lymphoma | Pten shRNA & miR-17~92 viruses | B lymphoma |
| Zuber J et al. (128) | Eμ-Myc;Trp53-/- | syngeneic | primary B lymphoma | Rpa3 shRNA viruses | B lymphoma |
| Malina A et al (138) | Eμ-Myc;p19ARF-/- | syngeneic | primary B lymphoma | Trp53 & Rosa26 sgRNA viruses | B lymphoma |
| Cao Z et al. (129) | Eμ-Myc, B6RV2 leukemia cells, primary human Burkitt's lymphoma | syngeneic or NSG | primary B lymphoma or B leukemia cell line | Notch1 Notch2 Hey1 & Jag1 shRNA viruses | B lymphoma |
| Hoellein A et al. (130) | Eμ-Myc | syngeneic | primary B lymphoma | Sae2 shRNA viruses | B lymphoma |
| Matthews GM et al. (131) | Eμ-Myc & Eμ-Myc;Hdac1-/- | syngeneic | primary B lymphoma | Hdac2 & Hdac3 shRNA viruses | B lymphoma |
| Duque-Afonso et al. (132) | E2A-PBX1;CD19.Cre & E2A-PBX1;Mx1.Cre | syngeneic | primary B ALL | Plcg2 shRNA virus | B ALL |
| Braun CJ et al. (134) | Eμ-Myc;p19ARF-/- & Bcr-Abl | syngeneic | primary B lymphoma | Trp53, Chek2 & 25 gene library sgRNAs & dCas9/dCas9-VP64 viruses | B lymphoma & B ALL |
| Li X et al. (133) | Eμ-Myc;p19ARF-/- | syngeneic | primary B lymphoma | Utx shRNA & Efnb1 ORF virus | B lymphoma |