Table 2.
Associations of CYP17A1 and SERPINA6/A1 SNPs in black South African men and women.
| Phenotype | Locus | SNP | Minor (Effect) allele | Linear regression model adjusted for confounders | ||
|---|---|---|---|---|---|---|
| Beta (95% CI) | p | Sex Int | ||||
| Fasting insulin | CYP17A1 | rs10883783 | A | −0.073 (−0.141, −0.005) | 0.035 | 0.011 |
| rs743575 | G | −0.072 (−0.140, −0.005) | 0.036 | 0.009 | ||
| rs4919687 | A | −0.072 (−0.139, −0.004) | 0.037 | 0.010 | ||
| rs10883784 | T | −0.067 (−0.134, 0.001) | 0.053 | 0.006 | ||
| rs10786714 | C | −0.067 (−0.135, 0.000) | 0.051 | 0.005 | ||
| HOMA-IR | CYP17A1 | rs10883783 | A | −0.085 (−0.157, −0.013) | 0.021 | 0.033 |
| rs743575 | G | −0.085 (−0.157, −0.014) | 0.020 | 0.029 | ||
| rs4919687 | A | −0.085 (−0.157, −0.013) | 0.020 | 0.030 | ||
| rs10883784 | T | −0.080 (−0.152, −0.008) | 0.029 | 0.021 | ||
| rs10786714 | C | −0.081 (−0.153, −0.009) | 0.028 | 0.020 | ||
| Fasting cortisol | CYP17A1 | rs115978957 | G | 0.132 (0.032, 0.232) | 0.010 | 0.047 |
| rs116032963 | A | 0.132 (0.032, 0.232) | 0.010 | 0.047 | ||
| Diastolic BP | SERPINA6/A1 | rs17090691 | G | 0.065 (0.036, 0.094) | 9.5 × 10−6 | 0.813 |
| HDL cholesterol | SERPINA6/A1 | rs60643124 | G | −0.021 (−0.036, −0.006) | 0.008 | 0.047 |
| rs12101216 | T | −0.018 (−0.032, −0.003) | 0.016 | 0.026 | ||
| rs74074941 | T | −0.016 (−0.032, −0.001) | 0.040 | 0.013 | ||
| rs74074947 | T | −0.016 (−0.032, −0.001) | 0.040 | 0.010 | ||
| rs58460454 | T | −0.017 (−0.032, −0.001) | 0.033 | 0.013 | ||
| rs1051052 | G | 0.016 (0.004, 0.028) | 0.008 | 0.006 | ||
Linear regression models adjusted for age, sex, smoking, alcohol, and BMI (except where waist circumference was the outcome); Blood sampling time was included as an additional covariate where cortisol was the outcome. SNP, single nucleotide polymorphism; M, major allele; m, minor allele; Beta, unstandardized beta coefficient for the linear regression model; 95% CI, 95% confident intervals; HOMA-IR, homeostatic model assessment of insulin resistance; HDL, high-density lipoprotein; BP, blood pressure; p, value of p for the unstandardized beta coefficient; Sex Int, value of p for sex interaction.