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. 2021 Aug 13;15:702961. doi: 10.3389/fnhum.2021.702961

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Copyright © 2021 Nakajima, Shimo, Fuse, Tokugawa, Hishii, Iwamuro, Umemura and Hattori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stimulation amplitude of adaptive deep brain stimulation (aDBS) and fluctuations in the beta band (16.60 ± 2.5 Hz) oscillation of the local field potential (LFP) over time for a long period (a) and a short period (b). Arrow in (b) indicates the timing of levodopa 100 mg /carbidopa 25 mg intake. Conventional DBS (cDBS) (outside the hospital): Stimulation was set at 2.2 mA. aDBS (inside and outside the hospital): Upper stimulation was set at 3.5 mA and lower at 0.7 mA. Strength of beta oscillation = Vin (v) * Gain * 16 (LSB) / 1.2 (v) Vin: input voltage to the analog to digital convertor, Gain = 250, LSB of an analog-to-digital convertor is 16 least significant bits, The analog-to-digital convertor has a voltage range of 1.2 v.