Fig. 8.

Schematic representation of Treg-related TRACs identified by RNAseq. The control of FoxP3 mRNA and protein expression is known to be controlled by many factors, including promoter methylation, as well as transcriptional regulation by SMYD3, TCF3/E2A, and IKZF4/Eos. FoxP3, in turn, is itself a transcriptional regulator, in association with cofactors such as TRIM28, IRF4, and others. The FoxP3-sensitive target genes, and other regulators such as AHRR, ICOS, TGF-ß, and mTOR, are then intrinsic components of the transition of Treg progenitor cells to functional Tregs. Molecular images courtesy of www.somersault1824.com under a Creative Commons license