Fig. 2.

An illustration of the drug homogeneous network generated in BiNE. Assuming that there are only three drugs and two targets in the whole bipartite DTI matrix $G_b$. When the $3\times 3$ drug homogeneous matrix is made by multiplying $G_b$ (the $3\times 2$ matrix) by $G_b^T$ (the $2\times 3$ matrix), we can find that, in this $3\times 3$ matrix, the value between Drug1 and Drug2 is 1, while the value between Drug1 and Drug3 is 0, and these values correspond to the DTI relations in $G_b$. Specifically, Drug1 and Drug2 share one target (Target2), Drug1 and Drug3 do not share any target, correspondingly, the value of the former drug pair in the drug homogeneous matrix is higher than that of the latter one