Table 5.
The novel interactions predicted by DTI-HeNE and corresponding evidence provided by external databases
| Drug ID | Drug names | Target ID | Target names | Evidence sources |
|---|---|---|---|---|
| Enzymes | ||||
| D00437 | Nifedipine | hsa1585 | CYP11B2 | M, CTD |
| D00528 | Caffeine | hsa50940 | PDE11A | CTD |
| D00126 | Ibuprofen | hsa247 | ALOX15B | M |
| D00394 | Trimipramine | hsa5152 | PDE9A | None |
| D00574 | Aminoglutethimide | hsa1589 | CYP21A2 | M |
| G-protein-coupled receptors | ||||
| D00513 | Pindolol | hsa152 | ADRA2C | None |
| D01713 | Epinastine | hsa152 | ADRA2C | C |
| D00454 | Olanzapine | hsa3357 | HTR2B | K, T, CTD |
| D02354 | Thiethylperazine | hsa1816 | DRD5 | C |
| D00283 | Clozapine | hsa1132 | CHRM4 | D, C, T |
| Ion channels | ||||
| D00524 | Carbachol | hsa1138 | CHRNA5 | CTD |
| D03365 | Nicotine | hsa1138 | CHRNA5 | K, D, T, CTD |
| D03826 | Physostigmine sulfate | hsa2564 | GABRE | None |
| D00550 | Midazolam | hsa2570 | GABRR2 | T, CTD |
| D00303 | Disopyramide | hsa6326 | SCN2A | K |
| Nuclear receptors | ||||
| D00585 | Mifepristone | hsa2099 | ESR1 | M, T, CTD |
| D00066 | Progesterone | hsa2100 | ESR2 | D, CTD |
| D01161 | Fulvestrant | hsa5241 | PGR | M, C |
| D00182 | Norethisterone | hsa2099 | ESR1 | CTD |
| D00066 | Progesterone | hsa367 | AR | DB, CTD |
| DrugBank | ||||
| DB01589 | Quazepam | P47870 | GABRB2 | T, K |
| DB00546 | Adinazolam | Q16445 | GABRA6 | K |
| DB00321 | Amitriptyline | P14416 | DRD2 | T |
| DB01215 | Estazolam | Q16445 | GABRA6 | K |
| DB00696 | Ergotamine | P41595 | HTR2B | D, C, T |