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. 2021 Aug 13;12:711904. doi: 10.3389/fphys.2021.711904

Table 1.

Characteristics of the included studies.

References Country Study design N Average age Disease
models
Outcomes Correlation r Effectors and CIs Relationship
Chen et al. (2021) China Cross-sectional 180 58 ± 14 CKD2-5 Valve calcification No data OR: 1.075 (1.027–1.126) Inverse
Xu et al. (2020) China Cross-sectional 112 60.13 ± 9.30 MHD AAC No data β: −3.128 (−4.499 to −1.758) Inverse
Before-after
Koga et al. (2020) Japan Cross-sectional 75 68 ± 9 CKD1-4 CAC −0.032, p = 0.006 OR: 6.94 (1.26–38.24) Inverse
No data
Zheng et al. (2018) China Cross-sectional 128 61.91 ± 15.39 MHD CAC −0.667, p = 0.001 OR: 1.033 (1.020–1.044) Inverse
Prospective
Krishnasamy et al. (2017) Australia Prospective 82 62.9 ± 10.2 CKD4-5 42 controls AAC −0.36, p = 0.002 No data No
Di Lullo et al. (2015) Italy Cross-sectional 100 51 (46–56) CKD3-4 Valve calcification −0.208; p = 0.04 No data No
Cai et al. (2015) China Cross-sectional 129 58.18 ± 13.72 MHD AAC −0.214, p = 0.015 OR:3.559 (1.453–8.717) Inverse
Morita et al. (2015) Japan Cross-sectional 157 W:65.8 ± 11.5 CKD2 CAC No data OR: CAC 2.0 (0.625–6.25) No
M:67.0 ± 11.6 CKD2 AVC No data OR: AVC 0.34 (0.11–1.02) No
Buiten et al. (2014) UK Cross-sectional 127 67 ± 7 MHD AAC No data β: 0.58 (−0.07–1.22) No
CAC No data β: 0.08 (−0.19–0.36) No
Kitagawa et al. (2013) Japan Cross-sectional 114 58 (47–66) CKD1-3 ACI No data β: −0.00226, p = 0.251 No

, Spearman relation; CKD, chronic kidney disease; MHD, maintenance hemodialysis; OR, odds ration; CI, confidence interval; ESKD, end stage kidney disease; W, women; M, men; MAC, medial arterial calcification; CAC, coronary artery calcification; AVC, aortic valve calcification; AAC, abdominal aorta calcification; ACI, aortic calcification index.