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. 2020 Dec 14;27(10):1497–1505. doi: 10.1177/1352458520972573

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — sNfL levels across time in patients classified as exhibiting NEDA or EDA: (a) patients classified as exhibiting NEDA for the entire duration of the study, n = 65 (NEDA for 4 years) and (b) patients classified as exhibiting EDA at any time during the study, n = 832 (EDA over 4 years). The average annualized PBVC is based on data collected at 6 months and at 1, 2, 3, and 4 years. Each line represents the sNfL data for an individual patient.

CV: coefficient of variation; EDA: evidence of disease activity; NEDA: no evidence of disease activity; PBVC: percent brain volume change; sNfL: serum neurofilament light chain.