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. 2021 Aug 13;12:701590. doi: 10.3389/fendo.2021.701590

Figure 1.

Figure 1

Schematic representation of experimental design and grouping. Female rats were implanted with letrozole-continuous-release pellets to establish PCOS-IR rat model. F0 female rats were randomly divided into PCOS-IR+Met, PCOS-IR, and Control groups and crossed with healthy male rats to obtain F1 offspring. F1 female offspring crossed with healthy male rat to obtain F2 offspring.