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. 2021 Aug 13;12:701590. doi: 10.3389/fendo.2021.701590

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Copyright © 2021 Xie, Xiao and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of metformin treatment on the endocrine and metabolic alterations in female F1 offspring. (A) Body weight changes in female F1 offspring (PCOS-IR group, n = 19; PCOS-IR+Met group, n = 48; Control group, n = 46). a P < 0.05 PCOS-IR vs. Control, b P < 0.05 PCOS-IR+Met vs. Control, c P < 0.05 PCOS-IR vs. PCOS-IR+Met, ANOVA; (B–E) Glucose, fasting insulin, HOMA-IR, and T changes in female F1 offspring (PCOS-IR group, n = 19; PCOS-IR+Met group, n = 48; Control group, n = 46). There were no significant changes during those groups, ANOVA.