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. 2021 Aug 13;11:723193. doi: 10.3389/fonc.2021.723193

Table 3.

The occurrence and comparison of acute toxic and side effects between the two groups.

Arms Classification of acute toxic reactions Number of cases (%) χ2 P
0 1 2 3 4
leukopenia Control 15 8 13 4 3 28 (65.12%). 1.062 0.303
Experimental 12 14 16 6 0 36 (75.00%).
Neutropenia Control 24 5 7 3 4 19 (44.19%). 5.588 0.018
Experimental 15 18 9 5 1 33 (68.75%).
thrombocytopenia Control 30 9 2 1 1 13 (30.23%). 0.276 0.599
Experimental 31 12 5 0 0 17 (35.42%).
Blood in the urine Control 22 14 6 0 1 21 (48.84%). 0.008 0.930
Experimental 25 16 6 1 0 23 (47.92%).
proteinuria Control 32 6 4 1 0 11 (25.58%). 0.653 0.419
Experimental 32 12 4 0 0 16 (33.33%).
hypertension Control 42 1 0 0 0 1 (2.33%). 0.032*
Experimental 40 8 0 0 0 8 (16.67%)
bleeding Control 34 7 2 0 0 9 (20.93%) 0.212 0.645
Experimental 36 11 1 0 0 12 (25.00%).
infection Control 35 4 2 2 0 8 (18.60%) 9.806 0.02
Experimental 24 16 8 0 0 24 (50.00%).
nausea Control 17 12 12 2 0 26 (60.47%). 3.957 0.046
Experimental 29 9 10 0 0 20 (41.67%).
vomiting Control 28 8 5 2 0 15 (34.88%). 1.062 0.303
Experimental 36 7 5 0 0 12 (25.00%).
diarrhea Control 32 6 2 3 0 11 (25.58%). 0.026 0.871
Experimental 35 10 3 0 0 13 (27.08%).
Skin damage* Control 34 8 0 0 1 9 (20.93%) 0.052 0.819
Experimental 37 10 1 0 0 11 (22.92%).
Lower alimentary canal and pelvic cavity* Control 35 5 2 1 0 8 (18.60%) 3.217 0.073
Experimental 31 8 8 0 1 17 (35.42%).
Genitourinary tract* Control 40 0 2 0 1 3 (6.98%) 0.323*
Experimental 41 5 1 1 0 7 (14.58%)
Radiation cystitis* Control 42 0 0 0 1 1 (2.33%). 1.00*
Experimental 46 1 0 1 0 2 (4.17%).
Radiation proctitis* Control 38 3 1 1 0 5 (11.63%) 0.173 0.677
Experimental 41 1 5 0 1 7 (14.58%)

*denotes radiation-related injury.