. 2021 Aug 13;11:723193. doi: 10.3389/fonc.2021.723193

Table 4.

The adjusted odds ratios through multivariate regression for clarifying the correlation between toxicological reactions and Endostar.

Variables		Neutropenia	Hypertension	Infection	Nausea
Age	OR (95%CI)	0.993 (0.939-1.051)	1.069 (0.951-1.203)	0.967 (0.909-1.028)	0.962 (0.910-1.019)
Age	P value	0.817	0.263	0.280	0.183
Height	OR (95%CI)	1.038 (0.944-1.141)	1.196 (0.969-1.476)	0.950 (0.858-1.052)	1.000 (0.911-1.097)
Height	P value	0.438	0.095	0.325	1.000
Weight	OR (95%CI)	0.964 (0.916-1.014)	0.957 (0.874-1.048)	1.002 (0.950-1.057)	1.016 (0.969-1.065)
Weight	P value	0.155	0.343	0.941	0.521
Level of education (Illiteracy versus literacy)	OR (95%CI)	2.35 (0.804-6.871)	1.198 (0.148-9.697)	1.870 (0.584-5.983)	2.317 (0.777-6.909)
Level of education (Illiteracy versus literacy)	P value	0.118	0.866	0.292	0.132
Having basis of disease (yes versus no)	OR (95%CI)	2.489 (0.739-8.380)	19.801 (2.663-147.237)	0.483 (0.133-1.746)	0.704 (0.226-2.197)
Having basis of disease (yes versus no)	P value	0.141	0.004	0.267	0.545
Menopause (after versus before)	OR (95%CI)	1.112 (0.391-3.169)	0.846 (0.098-7.312)	0.701 (0.232-2.121)	0.364 (0.124-1.072)
Menopause (after versus before)	P value	0.842	0.879	0.530	0.067
FIGO stages (IIB-IIIB versus IIIC-IVA)	OR (95%CI)	0.823 (0.251-2.691)	1.759 (0.102-30.364)	0.669 (0.180-2.484)	0.401 (0.119-1.349)
FIGO stages (IIB-IIIB versus IIIC-IVA)	P value	0.747	0.697	0.548	0.140
Tumor size (< 4 cm versus ≥4 cm)	OR (95%CI)	0.684 (0.470-3.161)	3.544 (0.541-23.207)	1.697 (0.622-4.634)	1.237 (0.487-3.145)
Tumor size (< 4 cm versus ≥4 cm)	P value	0.684	0.187	0.302	0.655
Arms (Control versus Experimental)	OR (95%CI)	2.885 (1.063-7.833)	9.660 (1.062-87.835)	4.455 (1.472-13.485)	0.268 (0.097-0.744)
Arms (Control versus Experimental)	P value	0.038	0.044	0.008	0.011