Figure 2.

NonTg mice explore more and drink less than 3xTg-AD mice in the adaptation phases. (A) During the 3-day adaptation phase, animals freely entered any of the four corners and could access water: cage not drawn to scale. (B) We found that NonTg mice made more corner visits on day 1 compared to 3xTg-AD mice (p < 0.05). We also found that the number of visits decreased from day 1–3 (p < 0.001). (C) No differences detected in total licks. In the 3-day nosepoke adaptation phase, animals must learn to nosepoke to access water. (D–F) No significant differences were detected in total visits, total visits with a nosepoke, and total licks. (G) We found that 3xTg-AD mice made more total visits to lick than NonTg mice on days 2 and 3 of nosepoke adaptation, illustrating increased motivation to enter a corner and nosepoke to drink. Data are presented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.