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. 2021 Aug 13;13:720214. doi: 10.3389/fnagi.2021.720214

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Copyright © 2021 Winslow, McDonough, Tallino, Decker, Vural and Velazquez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3xTg-AD mice show impairments in working memory during the place avoidance task. (A) For a 24-h period, entry into the assigned corner with a nosepoke resulted in an airpuff (~0.8 bar, 1 s airpuff); cage not drawn to scale. (B,C) We found that 3xTg-AD mice made more total visits (p < 0.05) and more visits to the airpuff corner with a nosepoke (p < 0.05) than the NonTg mice. (D) Mice were removed from the IntelliCage after the airpuff exposure and placed in a standard cage for 24 h, then returned to the IntelliCage to assess memory and extinction by measuring corner visits to the previously assigned airpuff corner; cage not drawn to scale. (E,F) No significant differences in total visits or % error with a nosepoke (i.e., visiting the airpuff corner from exposure) were detected. Data are presented as means ± SEM. *p < 0.05.