Table 3.
Association Between Change in DNAm Age Acceleration and Change in Age-Related Performance Between 53 years and 60–64 years Conditional on Baseline Performance at 53 years
| ΔGrip strength (kg) (n = 435) | ΔChair rise (stands/min) (n = 418) | ΔFEV1 (n = 451) | ΔNumber of words recalled (n = 456) | ΔTotal number of letters scanned (n = 464) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | |
| ΔAgeAccelHannum | 0.19 (–0.07, 0.44) | .15 | 0.03 (–0.14, 0.20) | .74 | 0.006 (–0.007, 0.019) | .34 | –0.01 (–0.13, 0.11) | .88 | 0.49 (–1.19, 2.17) | .56 |
| ΔAgeAccelHorvath | –0.06 (–0.28, 0.16) | .59 | –0.12 (–0.27, 0.03) | .12 | –0.002 (–0.013, 0.008) | .66 | 0.06 (–0.05, 0.17) | .25 | 1.31 (–0.17, 2.79) | .08 |
| ΔAgeAccelPheno | 0.03 (–0.14, 0.20) | .72 | –0.12 (–0.24, –0.01) | .04 | 0.006 (–0.003, 0.015) | .17 | 0.05 (–0.04, 0.13) | .25 | 0.16 (–0.98, 1.31) | .78 |
| ΔAgeAccelGrim | –0.04 (–0.18, 0.11) | .60 | –0.06 (–0.16, 0.04) | .23 | 0.006 (–0.001, 0.013) | .09 | 0.04 (–0.03, 0.11) | .27 | –0.91 (–1.87, 0.05) | .06 |