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. 2021 Aug 13;11:701336. doi: 10.3389/fonc.2021.701336

Table 2.

Group mean value of shear wave speed c in all 80 patients and collagen volume fraction (CVF) in a subgroup of 69 patients by pathology-based TN stage, LVI and PNI status, degree of tumor differentiation, prognostic stage, and risk level of all patients.

Prognostic factor No. of patients (total n=80) Shear wave speed c (m/s) p value No. of patients (total n=69) CVF p value
pT stage <0.0001 0.0086
pT1-2 32 2.0 ± 0.4 27 0.13 ± 0.11
pT3-4 48 2.4 ± 0.5 42 0.21 ± 0.12
pN stage 0.013 <0.0001
pN0 54 2.2 ± 0.6 45 0.12 ± 0.091
pN1-2 26 2.5 ± 0.4 24 0.29 ± 0.097
LVI 0.017 0.1675
Negative 68 2.2 ± 0.5 57 0.17 ± 0.12
Positive 12 2.6 ± 0.5 12 0.23 ± 0.12
PNI 0.018 0.0269
Negative 72 2.2 ± 0.5 61 0.17 ± 0.12
Positive 8 2.7 ± 0.5 8 0.27 ± 0.11
Degree of tumor differentiation 0.040 0.0007
Well to moderately differentiated 71 2.2 ± 0.5 62 0.17 ± 0.11
Poorly differentiated 9 2.6 ± 0.5 7 0.32 ± 0.084
Prognostic stage 0.0022 <0.0001
Stage 0-I 26 1.9 ± 0.5 22 0.010 ± 0.082
Stage II-III 27 2.3 ± 0.6 20 0.15 ± 0.085
Stage III-IV 27 2.5 ± 0.4 27 0.27 ± 0.11
Risk stratification <0.001 <0.001
Low-risk 44 2.1 ± 0.5 37 0.11 ± 0.08
High-risk 36 2.5 ± 0.5 32 0.27 ± 0.10

CVF, collagen volume fraction; LVI, lymphovascular invasion, PNI, perineural invasion. Prefix p in the stages represents pathology.