Table 2.

List of the significantly dysregulated PIWI-interacting RNAs in GBM patients compared to non-tumor controls based on next-generation sequencing data.

Upregulated piRNAs in GBM				Downregulated piRNAs in GBM
piRNA	logFC	AveExpr	adj. p-value	piRNA	logFC	AveExpr	adj. p-value
piR-hsa-5938	1.429	17.409	<0.001	piR-hsa-12488	−2.355	10.116	<0.001
piR-hsa-28319	1.851	9.843	<0.001	piR-hsa-12487	−2.335	9.971	<0.001
piR-hsa-18709	1.700	10.275	<0.001	piR-hsa-9491	−3.159	8.670	<0.001
piR-hsa-5937	1.123	16.535	<0.001	piR-hsa-1849	−1.875	10.348	<0.001
piR-hsa-1207	1.342	16.538	<0.001	piR-hsa-26683	−1.953	11.898	<0.001
piR-hsa-28131	1.341	16.538	<0.001	piR-hsa-26686	−1.883	11.842	<0.001
piR-hsa-1282	1.102	12.993	<0.001	piR-hsa-26685	−1.848	11.778	<0.001
piR-hsa-25781	1.189	10.880	<0.001	piR-hsa-26682	−1.844	11.765	<0.001
piR-hsa-28877	1.147	17.55	<0.001	piR-hsa-26684	−1.826	11.748	<0.001
piR-hsa-25780	1.099	10.725	0.001	piR-hsa-26681	−1.825	11.742	<0.001
piR-hsa-24672	0.846	16.164	0.001	piR-hsa-24684	−1.17	9.249	0.001
piR-hsa-28876	0.881	9.845	0.006	piR-hsa-25783	−0.904	12.762	0.002
piR-hsa-27493	0.856	13.67	0.007	piR-hsa-28467	−0.949	10.640	0.007
piR-hsa-28487	0.821	10.189	0.015	piR-hsa-27616	−0.807	8.783	0.01
piR-hsa-1281	0.787	10.073	0.019	piR-hsa-27731	−0.718	9.427	0.052
piR-hsa-1580	0.742	8.714	0.019
piR-hsa-28189	0.742	8.714	0.019
piR-hsa-25782	0.614	11.677	0.025
piR-hsa-23209	1.114	8.802	0.028
piR-hsa-27622	0.724	15.945	0.025
piR-hsa-27140	0.774	13.97	0.028
piR-hsa-7193	0.706	9.222	0.03
piR-hsa-28188	0.669	8.315	0.04

Five piRNAs in bold were selected for further validation by qRT-PCR.

log Fold Change = logFC, average expression = AveExpr, adjusted p-value = adj. p-value