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. 2021 Aug 13;12:717529. doi: 10.3389/fphar.2021.717529

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Copyright © 2021 Zhou, Wu, Ning, Wu, Xu, Ma, Li, Hu, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ivermectin inhibits cell proliferation of SW480 and SW1116 cells. SW480 (A) and SW1116 cells (B) were cultured at different concentrations of ivermectin (0, 2.5, 5, 10, 15, 20, and 30 μM) for 12, 24, and 36 h, and then CCK-8 assay was performed to detect the cell proliferation. The experiment was repeated three times, and data were presented as mean ± S.E.M. The interaction between dose (D) and time (T) effect were analyzed using two-way ANOVA following Tukey’s t-test. D: dose effect; T: time effect: T × D: the interaction between time and dose effect.