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. 2021 Aug 13;12:717529. doi: 10.3389/fphar.2021.717529

FIGURE 4.

FIGURE 4

Ivermectin induced apoptosis in colorectal cancer cells. SW480 and SW1116 cells were treated with different concentrations of ivermectin (0, 5, 10, and 20 μM) for 6 h and then were stained, described in the “Materials and Methods” section. The total percentage of apoptosis is equal to the percentage of early apoptosis (Q2, Annexin V+7-AAD-) plus the percentage of late apoptosis (Q3, Annexin V+7-AAD+). Representative images from flow cytometry were shown in (A). Data for SW480 (B) and SW480 (C) cells were summarized and analyzed using one-way ANOVA following Tukey’s t-test. The data are shown as the means ± S.E.M. of three independent experiments. (a–d): same letters, no statistical difference; different letters, the statistical difference (p < 0.05). IVM, ivermectin.