TABLE 2.

Synergy between goat cathelicidins ChDode and ChMAP-28.

Strain	ChDode, μM			ChMAP-28, μM			Minimal FICI*	Synergy
	MICA	[A]	FICA	MICB	[B]	FICB
E. coli ML-35p	16	0.5	0.031	0.06	0.008	0.125	0.156	Yes
S. aureus 209P	>64	8	<0.125	0.5	0.03	0.063	<0.188	Yes

*The estimation of synergistic effects between cathelicidins was performed by calculating the fractional inhibitory concentration index (FICI) according to the equation: FICI = FIC_A + FIC_B = [A]/MIC_A + [B]/MIC_B, where MIC_A and MIC_B are MICs of individual peptides, while [A] and [B] are MICs of A and B when used together. A synergistic effect was defined at a FICI ≤ 0.5. The table shows the lowest value of FICI, reproduced in three independent experiments.