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. 2021 Aug 13;12:693142. doi: 10.3389/fimmu.2021.693142

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Copyright © 2021 Gokuladhas, Schierding, Golovina, Fadason and O’Sullivan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shared genes display predominant role in AiD modules. (A) Heatmap of proportion of genes/proteins from each AiD that were attributed to modules 1-14. Dark shaded square indicates higher proportions of proteins. (B) The proportion of shared, disease-specific and identical proteins present in the top 5 enriched biological pathways (KEGG), by module. (C) The proportion of disease-specific, shared and identical proteins that constitutes central nodes within each module. (D) The central proteins in 13 modules are targeted by FDA approved drugs, of which 45% proteins are shared between diseases. Proteins that are targeted by more than 20 drugs are labeled.