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. 2021 Aug 13;12:693142. doi: 10.3389/fimmu.2021.693142

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Copyright © 2021 Gokuladhas, Schierding, Golovina, Fadason and O’Sullivan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HLA genes are central to immune function rich module. (A) Network representation of Module 1. The color of the nodes denotes the disease with which the protein is associated. Node shape indicates if the SNP acts locally (cis - circle), distally (trans - diamond), or both (cis and trans – rounded square) on the genes encoding proteins. Central nodes are highlighted in red borders and labelled. Cytoscape (version 3.8.2) was used for visualization of the module. (B) Relatively greater proportions of proteins (>40%) in the Module 1 are enriched for transport, localization and immune processes. The top 30 enrichment results are shown (FDR ≤ 6.01e-14) (C) KEGG pathway enrichment analysis identified enrichment in immune related pathways (FDR<0.05). In (B, C), the numbers on top of each bar denote the number of proteins enriched for that term/pathway, and the asterisk denotes that the term/pathway is also enriched for shared proteins that are central to the network (Supplementary Data 10 Tables 4, 5).