Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 13;12:693142. doi: 10.3389/fimmu.2021.693142

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Gokuladhas, Schierding, Golovina, Fadason and O’Sullivan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The largest network module is enriched for cellular signaling and cancer pathways. (A) Network representation of the module. The color of the nodes denotes the disease with which the protein is associated. Node shape indicates if the SNP acts locally (cis - circle), distally (trans - diamond), or both (cis and trans – rounded square) on the genes encoding proteins. Central nodes are highlighted in red borders and labelled. Cytoscape (version 3.8.2) was used for visualization of the module. (B) Module 7 is enriched for signaling and metabolic processes. The top 30 enrichment results are shown (FDR ≤ 4.77E-36). (C) KEGG pathway enrichment analysis identified enrichment in signaling and cancer related pathways (FDR ≤ 3.70E-09). The top 30 pathway enrichment results are shown. In (B, C), the numbers, to the right of each bar, denote the number of proteins enriched for that term or pathway. The asterisk designates terms or pathways that were enriched for shared proteins that are central to the network (Supplementary Data 12 Tables 4, 5 respectively).