Figure 6.

Roles of hypoxia risk score in the Xiangya cohort. (A) Correlations between hypoxia risk score and the activities of the cancer immunity cycles. (B) Correlations between hypoxia risk score and the enrichment scores of immunotherapy-predicted pathways. (C) Correlations between hypoxia risk score and immune checkpoints. (D) Correlations between hypoxia ris score and the T cell inflamed score (TIS). (E) Correlations between hypoxia risk score and the infiltration levels of five tumor infiltrating immune cells (CD8+ T cells, NK cells, macrophages, Th1 cells, and dendritic cells). (F) The associations between the hypoxia risk score groups and the molecular subtypes in seven different algorithms. (G) The predictive accuracy of hypoxia risk score for molecular subtypes in seven different algorithms. (H) Correlations between hypoxia risk score and the enrichment scores of several therapeutic signatures such as targeted therapies and radiotherapy.