Figure 4.

Mitochondrial fission machinery. The steps involved in mitochondrial fission are as follows- ER tubules contact the mitochondria to mediate constriction before the recruitment of DRP1. After the recruitment of DRP1 to the OMM, it forms a ring like structure, GTP hydrolysis of DRP1 then occurs followed by the recruitment of DNM2 to the mitochondrion-constricted site, where it assembles and completes the division process leading to two daughter mitochondria. ER- Endoplasmic reticulum, DRP1- Dynamin related protein 1, DNM2- Dynamin 2, GTP- Guanosine triphosphate, GDP- Guanosine diphosphate, Pi- inorganic phosphate, OMM- Outer mitochondria membrane.