Table 1–

A list of fusion and fission associated genes, their functions, reported alterations and associated diseases.

Gene Name	Yeast Orthologue	Functions	Alterations	Diseases
MFN1	Fzo1	Outer mitochondrial membrane fusion	Mfn1 downregulation	Hepatocellular carcinoma (97, 98), Triple negative breast cancer (99)
MFN2	Fzo1	Outer mitochondrial membrane fusion	Heterozygous mutations in Mfn 2Mfn2 downregulation	Charcot Marie Tooth Disease type 2A (4)Breast cancer (100)
OPA1	Mgm1	Inner mitochondrial membrane fusion	Mutations (mostly missense)	Dominant optic atrophy (68).
DRP1	Dnm1	Mitochondrial fission	Increased Drp1 phosphorylation levels.	Sporadic Parkinson’s disease (81) Diseases
DRP1	Dnm1	Mitochondrial fission	Increased phosphorylation of Drp1 at serine 616 Increased expression levels of Drp1 Increased Drp1 mRNA expression and protein levels Drp1 upregulation	Pancreatic ductal adenocarcinoma (50), Glioblastoma (101). Left ventricular hypertrophy (85), Lung adenocarcinomas (102). Hepatocellular carcinoma (97). Triple negative breast cancer (99)