Table 1.
Number of Clinical Outcomes Averted With Norovirus Vaccination Compared With No Vaccination (2,500-Person Population)
| Vaccination scenario | Total norovirus cases averted Mean (95% CI) | Symptomatic cases averted Mean (95% CI) | Deaths averted Mean (95% CI) | Missed productive days averted Mean (95% CI) | Ambulatory care visits averted Mean (95% CI) | Hospitalizations averted Mean (95% CI) |
|---|---|---|---|---|---|---|
| Vaccinating preschool-aged children (aged 0–4 years) | ||||||
| 25% vaccine efficacy | ||||||
| 10% coverage | 19.8 (19.5, 20.1) | 13.6 (13.4, 13.8) | 0.01 (0.01, 0.01) | 37.1 (36.7, 37.5) | 1.2 (1.1, 1.3) | 0.06 (0.04, 0.08) |
| 45% coverage | 79.4 (79.1, 79.7) | 54.2 (54.0, 54.4) | 0.01 (0.01, 0.01) | 140.5 (140.1, 140.8) | 4.8 (4.7, 4.8) | 0.24 (0.22, 0.26) |
| 80% coverage | 113.7 (113.5, 114.0) | 77.6 (77.4, 77.8) | 0.02 (0.02, 0.02) | 201.1 (200.8, 201.5) | 6.8 (6.8, 6.9) | 0.34 (0.32, 0.36) |
| 50% vaccine efficacy | ||||||
| 10% coverage | 41.7 (41.4, 42.0) | 28.5 (28.3, 28.7) | 0.01 (0.01, 0.01) | 73.3 (73.0, 73.7) | 2.5 (2.4, 2.6) | 0.12 (0.11, 0.13) |
| 45% coverage | 130.0 (129.7, 130.2) | 88.3 (88.1, 88.5) | 0.02 (0.02, 0.02) | 223.0 (222.7, 223.3) | 7.8 (7.7, 7.8) | 0.38 (0.37, 0.39) |
| 80% coverage | 166.4 (166.1, 166.6) | 113.0 (112.8, 113.2) | 0.02 (0.02, 0.02) | 284.8 (284.5, 285.1) | 9.9 (9.8, 9.9) | 0.49 (0.48, 0.50) |
| 75% vaccine efficacy | ||||||
| 10% coverage | 59.1 (58.8, 59.4) | 40.3 (40.1, 40.5) | 0.01 (0.01, 0.01) | 101.6 (101.2, 101.9) | 3.6 (3.5, 3.6) | 0.18 (0.17, 0.19) |
| 45% coverage | 158.7 (158.5, 159.0) | 107.7 (107.5, 107.9) | 0.02 (0.02, 0.02) | 270.8 (270.5, 271.1) | 9.4 (9.4, 9.5) | 0.47 (0.46, 0.48) |
| 80% coverage | 186.3 (186.1, 186.5) | 126.5 (126.3, 126.6) | 0.02 (0.02, 0.02) | 316.6 (316.3, 316.8) | 11.1 (11.0, 11.1) | 0.55 (0.54, 0.56) |
| Vaccinating older adults (aged ≥65 years) | ||||||
| 25% vaccine efficacy | ||||||
| 10% coverage | 3.9 (3.6, 4.1) | 3.3 (3.0, 3.5) | 0.01 (0.01, 0.01) | 8.1 (7.7, 8.5) | 0.3 (0.2, 0.4) | 0.03 (0.01, 0.05) |
| 45% coverage | 15.9 (15.6, 16.2) | 13.5 (13.2, 13.7) | 0.01 (0.01, 0.01) | 36.2 (35.8, 36.6) | 1.2 (1.1, 1.2) | 0.10 (0.08, 0.12) |
| 80% coverage | 25.1 (24.8, 25.4) | 21.5 (21.3, 21.8) | 0.01 (0.01, 0.01) | 56.0 (55.6, 56.4) | 1.9 (1.8, 1.9) | 0.16 (0.15, 0.17) |
| 50% vaccine efficacy | ||||||
| 10% coverage | 7.0 (6.7, 7.3) | 6.0 (5.8, 6.3) | 0.01 (0.01, 0.01) | 16.1 (15.8, 16.5) | 0.5 (0.4, 0.6) | 0.05 (0.03, 0.07) |
| 45% coverage | 30.7 (30.4, 30.9) | 25.6 (25.4, 25.8) | 0.01 (0.01, 0.01) | 62.4 (62.1, 62.8) | 2.2 (2.1, 2.3) | 0.19 (0.18, 0.20) |
| 80% coverage | 45.9 (45.6, 46.2) | 38.5 (38.3, 38.7) | 0.02 (0.02, 0.02) | 96.5 (96.1, 96.9) | 3.3 (3.3, 3.4) | 0.28 (0.27, 0.29) |
| 75% vaccine efficacy | ||||||
| 10% coverage | 11.5 (11.2, 11.8) | 9.7 (9.4, 9.9) | 0.01 (0.01, 0.01) | 23.8 (23.4, 24.2) | 0.8 (0.8, 0.9) | 0.07 (0.05, 0.09) |
| 45% coverage | 42.0 (41.7, 42.3) | 35.0 (34.7, 35.2) | 0.02 (0.02, 0.02) | 88.1 (87.8, 88.5) | 3.0 (3.0, 3.1) | 0.25 (0.24, 0.26) |
| 80% coverage | 59.9 (59.6, 60.2) | 50.1 (49.9, 50.3) | 0.02 (0.02, 0.02) | 124.6 (124.2, 124.9) | 4.3 (4.2, 4.4) | 0.37 (0.36, 0.38) |
Note: When vaccinating preschool-aged children: 10% coverage=15, 45% coverage=68, 80% coverage=121; when vaccinating older adults: 10% coverage=40, 45% coverage=180, 80% coverage=320.