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(A) Intramolecular transamidative peptide cyclization catalyzed by serine proteases such as PCY1. (B) WebLogo representation of PRMP octa- (top) and heptapeptides (bottom) with a C-terminal Pro. (C) Representative phylum-level microbiome architectures for Axinella,[6] Stylissa,[6] Phakellia,[20] and Hymeniacidon[20] spp. sponges. Microbiome diversity is denoted by Shannon indices. Shannon indices for HMA sponges are typically greater than 4.
