FIGURE 4.

A schematic illustration of the interaction of lncRNA NORAD and FUBP1 in endometrial cancer. FUBP1 is a master transcriptional regulator of various genes via interacting with FUSE. FUBP1 protein level is upregulated in the S phase. Reducing in the expression level of FUBP1 could affect cell cycle progression, particularly in the S phase, via downregulating Ccna gene theat encodes cyclin A. Fubp1-cyclin A axis could play a crucial role in triggering various types of cancers. Heterogeneous expression patterns of Fubp1 could be seen among several cancer tissues, illustrating its multiple and sophisticated functions in cancer development (Han et al., 2020). Accumulating evidence elucidates that epigenetic inactivation of NORAD could promote cell growth and reduce apoptosis in endometrial cancer cells. NORAD/FUBP1 interaction could inhibit FUBP1 nuclear localization, and thereby downregulating the recruitment of FUBP1 on promoters of target pro-apoptotic genes, triggering apoptosis in tumor cells (Han et al., 2020).