Fig. 4.

(A) Surface representation of the significant (p < 0.05 FDR corrected) post-hoc paired-t values for post-tiagabine vs pre, for activity measures in each frequency band. The post-drug session depicted was chosen based on the session showing the maximum number of significant voxels. For delta and theta, this was 3 hr post tiagabine vs pre, whereas for alpha and beta it was 5 hr post tiagabine vs pre. Colour axis represents direction of effect, with red/yellow representing significant, positive t-values, blue/purple representing significant negative t-values and black representing non-significant voxels. (B) Summary of the source activity post-hoc paired-t effects for post-drug vs pre for each session. (inset a) shows the number of significant (p < 0.05 FDR corrected) voxels for each frequency band. (inset b) shows the corresponding peak significant paired t-value for each comparison (x-axis) and frequency band. For clarity, the strongest positive and negative t-values are presented separately. Note that the Placebo (PLA) and Tiagabine (TGB) sessions were performed on different days. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)