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. 2021 Aug 16;12:719880. doi: 10.3389/fphar.2021.719880

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Copyright © 2021 Li, Sun, Hua, Suo, Chen, Yu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential therapeutic targets in the Wnt/β-catenin signaling. Numerous small molecules inhibit Wnt/β-catenin signaling at different steps of the pathway. Porcupine inhibitors prevent Wnt ligands secretion. Receptor or co-receptor inhibitors prevent the receptor actions of Wnt ligands. Inhibitors of GSK3β, axin, DVL, and CK1 interfere with Wnt/β-catenin downstream signaling. Inhibitors of TCF/LEF suppress Wnt/β-catenin-dependent gene transcription. Several natural products alleviate renal fibrosis by regulating the Wnt/β-catenin signaling pathway.