TABLE 1.

Summary of small molecular inhibitors of Wnt/β-catenin signaling.

Inhibitors	Targets	Effect	Reference(s)
Sfrp1	FZD	Ameliorates renal fibrosis	Henderson et al. (2020)
Klotho	Wnt ligands	Ameliorates renal fibrosis	Zhang et al. (2018a)
DDK1	LRP5/6	Ameliorates renal fibrosis	Lipphardt et al. (2019)
Wif1	Wnt ligands	Ameliorates fibrosis	Lin et al. (2017)
Wnt-c59	PORCN	Prevents Wnt ligands secretion	Proffitt et al. (2013)
LGK974	PORCN	Prevents Wnt ligands secretion	Moon et al. (2017)
IWP2	PORCN	Prevents Wnt ligands secretion	Wang et al. (2013a)
IWP-L6	PORCN	Prevents Wnt ligands secretion	Wang et al. (2013a)
SB-216763	GSK-3β	Inhibits Wnt signaling	Zhang et al. (2018b)
SCIs	GSK-3β	Inhibits Wnt signaling	Rippin et al. (2020)
CHIR99021	GSK-3β	Inhibits Wnt signaling	Ng-Blichfeldt et al. (2019)
L807mts	GSK-3β	Inhibits Wnt signaling	Licht-Murava et al. (2016)
LY2090314	GSK-3β	Inhibits Wnt signaling	Tu et al. (2017)
XAV939	Tnks and axin	Inhibits Wnt signaling	Kulak et al. (2015)
IWR	Tnks and axin	Inhibits Wnt signaling	Kulak et al. (2015)
E-7449	Tnks and axin	Inhibits Wnt signaling	Plummer et al. (2020)
K-476	Tnks and axin	Inhibits Wnt signaling	Kinosada et al. (2021)
BMD4722	DVL	Inhibits Wnt signaling	Ma et al. (2018)
IC261	CK1	Inhibits Wnt signaling	Xian et al. (2021)
ICG-001	CBP	Inhibits Wnt signaling	Akcora et al. (2018)
PRI-724	CBP	Inhibits Wnt signaling	Nishikawa et al. (2018)
PAA	Wnt/β-catenin signaling	Ameliorates fibrosis	Chen et al. (2019a)
PZC	Wnt/β-catenin signaling	Ameliorates fibrosis	Wang et al. (2018a)
PZD	Wnt/β-catenin signaling	Ameliorates fibrosis	Wang et al. (2018b)
PZE	Wnt/β-catenin signaling	Ameliorates fibrosis	Wang et al. (2018a)
PZG	Wnt/β-catenin signaling	Ameliorates fibrosis	Wang et al. (2018a)
PZH	Wnt/β-catenin signaling	Ameliorates fibrosis	Wang et al. (2018b)
MAF	Wnt/β-catenin signaling	Inhibits RSA	Chen et al. (2018a)
Ergone	Wnt/β-catenin signaling	Repress ECM accumulation	Chen et al. (2017a)
Alisol B 23-acetate	Wnt/β-catenin signaling	Repress ECM accumulation	Chen et al. (2017b)
Pachymic acid B	Wnt/β-catenin signaling	Repress ECM accumulation	Chen et al. (2017a)
Curcumin	Wnt/β-catenin signaling	Repress ECM accumulation	Ho et al. (2016)
Salvia	Wnt/β-catenin signaling	Relieve renal injury	Xiang et al. (2019)
Salidroside	Wnt/β-catenin signaling	Ameliorates fibrosis	Shati and Alfaifi (2020)
TW	Wnt/β-catenin signaling	Relieve renal injury	Chang et al. (2018)
Triptonide	Wnt/β-catenin signaling	Relieve renal injury	Chinison et al. (2016)
AS-IV	Wnt/β-catenin signaling	Ameliorates fibrosis	Wang et al. (2014a)
Quercetin	Wnt/β-catenin signaling	Ameliorates fibrosis	Ren et al. (2016)