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. 2021 Aug 31;9:e12072. doi: 10.7717/peerj.12072

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©2021 Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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This study firstly experimentally demonstrated the therapeutic effect of daidzein on osteosarcoma, then through the exploration of network pharmacology and molecular docking technology, key molecules and pathways were targeted and experimentally validated. Website links: DigSeE (Kim et al., 2013), DisGeNET (http://www.disgenet.org/), GeneCards (https://www.genecards.org/) KEGG disease (https://www.kegg.jp/kegg/disease/) MalaCards (http://www.malacards.org/) Phenopedia (https://phgkb.cdc.gov/PHGKB/startPagePhenoPedia.action) PubChem (https://pubchem.ncbi.nlm.nih.gov/) PharmMapper (http://www.lilab-ecust.cn/pharmmapper/) VENNY 2.1.0 (https://bioinfogp.cnb.csic.es/tools/venny/).