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. 2021 Aug 31;9:e12081. doi: 10.7717/peerj.12081

Figure 1. STRING protein-protein interaction network among the altered glycogenes in cervical cancer in comparison with a normal cervix.

Figure 1

(A) Interaction among the upregulated glycogenes shows two predicted cellular processes: the glycosylphosphatidylinositol (GPI) biosynthesis process (in red) and an immune system response process (in blue). (B) Interaction among the downregulated glycogenes shows the predicted network between HYAL2 and HAS3 in the hyaluronan metabolic process (in yellow). (C) Interaction among the upregulated glycogenes with five predicted interactors shows that the glycogenes PIGC and PIGN interact with more glycogenes of the GPI biosynthesis process (in red), while CHI3L1 and HEXB are predicted to interact with FUCA2 in the neutrophil degradation process (in green). (D) Interaction among the downregulated glycogenes and their respective predicted interactors shows four networks: HYAL2 and HAS3 along with CD44 participate in the hyaluronan metabolic process (in yellow); also, HAS3 is predicted to interact with UGP2 in pentose and glucuronate interconversions (in purple), glycogen biosynthetic process (in brown) and starch and sucrose metabolism (in gold). In addition, the glycogene CHST12 was predicted to interact with CHST3 and CHST7 in the chondroitin sulfate/dermatan sulfate biosynthesis process (in violet)