Figure 1.

Overall structure of influenza polymerase. (A) Schematic of the three subunits showing major domains. Colors used throughout this review are PA-N endonuclease (dark green), PA linker (light green), PA-C (medium green), PB1 (cyan), PB2-N (red), PB2 midlink (purple), PB2 cap-binding domain (orange), PB2 627 domain (salmon), PB2 NLS domain (dark red). (B) Front and back views of influenza polymerase in the transcription active conformation in surface (top) and ribbon (bottom) representation showing the major domains colored as in A. Drawn from PDB: 4WSB.