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. 2021 Aug 16;12:666300. doi: 10.3389/fgene.2021.666300

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Copyright © 2021 Ge, Hua, Chen, Xiao, Zhang, Zhou, Liang and Tai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between the prognostic signature and clinicopathological factors of PCa patients. (A) The heat map shows the expressions of the five costimulatory molecule genes and clinicopathological factors in the high- and low-risk groups. The univariate (B) and multivariate (C) Cox regression analyses of clinicopathological factors (including the risk score) and prognosis. The bar chat showed that the prognostic signature had significantly different in different clinical subgroups, and the PCa patients with advanced age (D), high pathological T stage (E), node metastasis (F), high Gleason score (G), high prostate-specific antigen (H), and recurrence (I) tend to have a high risk score. ns: P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.