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. 2021 Sep;31(9):1629–1637. doi: 10.1101/gr.275677.121

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© 2021 Sauteraud et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Genes that escape XCI are differentially expressed. Adjusted differential expression (DE) P-values as reported by limma for 215 genes against the frequency of samples that escape XCI as predicted by XCIR in Geuvadis. The dashed line indicates the 5% significance cutoff, and the significantly differentially expressed genes are colored based on the sex in which increased expression is observed. Escape genes are mostly female-biased, reflecting expression from both X copies. PAR genes (triangles) are correctly identified as escaping XCI despite most of them not being significantly differentially expressed, as the expression on the Y is similar or higher to that on the Xi.