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. 2021 Sep;31(9):1629–1637. doi: 10.1101/gr.275677.121

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© 2021 Sauteraud et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Genes that escape and variably escape XCI are enriched for heritability. (A) Distribution of heritability enrichment for all self-reported phenotypes available in females (240 phenotypes), males (218 phenotypes), or both (280 phenotypes). Heritability was independently assessed for each XCI state: escape (E), variably escape (VE), and silenced (S). X genes with Y homologs that escape or variably escape are differentiated (Y homolog). (B) Lupus heritability enrichment measured in females (392 cases, 182,316 controls).