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. 2021 Aug 16;12:705623. doi: 10.3389/fphar.2021.705623

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Copyright © 2021 Baratta, Del Buono, Schlumpf, Ceresa and Calkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CMP realigns collagen fibers damaged by collagenase in vitro. (A) Edge-enhanced differential interference contrast images of applied type I collagen damaged by collagenase and treated with a vehicle (top) or CMP (bottom). Example vectors (dashed lines) assigned by algorithm show a higher degree of parallelism in CMP-treated preparations. (B) Vectors in preparations treated with CMP have a higher average tendency for parallel alignment compared to a vehicle (*: p < 0.001). Data: mean ± SEM; n = 7.