Table 4.
Characteristics and outcomes of six patients with relapse.
Patient No. | Diagnosis | High-Risk Factor at Diagnosis | Disease Status at HSCT | Starting Time of Decitabine (days) | Cycles of Decitabine | Reason for Discontinuation of Decitabine | Bone Marrow Results at Relapse | Time From HSCT to Relapse (days) | Treatment After Relapse | Overall Survival (days) |
---|---|---|---|---|---|---|---|---|---|---|
16 | B-ALL | Ph+
WBC >100×109/L |
CR1 | 63 | 5 | Withdrew consent | Marrow blast 97.6% T315I mutation |
276 | DLI + chemotherapy | 433 |
2 | B-ALL | CD10− | CR1 | 97 | 8 | Completed study | Extramedullary | 551 | Chemotherapy; TBI; DLI |
725 |
17 | B-ALL | Ph+
Age >35 |
CR2 | 110 | 2 | Relapse | Marrow blast 42% T315I mutation |
168 | Automatic discharge | 213 |
3 | B-ALL | No | CR2 | 84 | 3 | Relapse | Marrow blast 49.6% | 205 | Automatic discharge | 244 |
30 | T-LBL | Leukemic phase; WBC>100×109/L | CR1 | 93 | 3 | Relapse | Extramedullary | 156 | Chemotherapy | >205 |
18 | B-ALL | Ph+ | CR1 | 60 | 5 | Relapse | Marrow blast 16.4% | 221 | Chemotherapy | >427 |
WBC, white blood cell; CR, complete remission; DLI, donor lymphocyte infusion; HSCT, hematopoietic stem cell transplantation.