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. 2021 Aug 16;11:684704. doi: 10.3389/fcimb.2021.684704

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Copyright © 2021 Dhungana, Nepal, Regmi and Malla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the experimental design. (A) In PK/PD model, SM buffer (vehicle control) and same dose of purified øKp_Pokalde_002 (phage only control) was administered via both IP and oral route. (B) In Kp56 infection model, bacteria (K. pneumoniae) were administered via IP route only, while treatment (øKp_Pokalde_002) was administered via both IP and oral route. Figure created in BioRender.com. PK, pharmacokinetics; PD, pharmacodynamics; SM, Sodium Magnesium; IP, intraperitoneal.