Figure 2.

Pharmacokinetics of øKp_Pokalde_002 in vivo via IP and oral route in the absence of host bacteria Kp56. The phage concentration in log₁₀ PFU/ml in blood, lungs, liver, spleen, and kidney after 1, 4, 8, 24, 48, and 72 h of phage administration via IP (A) and oral (C) route (200 µl of ~1 x 10⁸ PFU/ml). The result represents the mean from three independent experiments. Biodistribution of øKp_Pokalde_002 via IP (B) and oral (D) route at 4 h and 8 h, respectively. The dotted vertical line indicates T_max. Percentage recovery was calculated by dividing phage titer at the respective time-point by the administered dose (n = 3 mouse per time point).