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. 2021 Aug 23;78(4):1053–1066. doi: 10.1161/HYPERTENSIONAHA.121.17927

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© 2021 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Ang II (angiotensin II) increased the cardiac and renal collagen deposition detected by Masson’s Trichrome staining in 6β-hydroxytestosterone (6βOHT)-treated orchidectomized (Orchi)-cPLA₂α^+/+/Cyp1b1^+/+ and intact male cPLA₂α^+/+/Cyp1b1^/ but not in Orchi-cPLA₂α//Cyp1b1^+/+ mice. A, Representative images of heart and kidney. B, Quantitation of cardiac collagen deposition. C, Quantitation of renal collagen deposition. Saline was used as vehicle control for Ang II. Data are Mean±SEM (n=3/group). A 1-way ANOVA followed by Tukey multiple comparisons in B and C.