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. 2021 Aug 15;78(4):1067–1079. doi: 10.1161/HYPERTENSIONAHA.121.17567

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© 2021 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — sFLT1 (soluble fms-like tyrosine kinase-1) induces secondary organ failure in maternal kidney and aorta. A, Masson Goldner trichrome (MGT; scale bar: 200 µm) and Verhoeff Van Gieson (VVG; scale bar: 50 µm) stained maternal aortas (18.5 days postconception [dpc]) exhibited [B] a reduced aortic lumen/wall ratio and [C] an increased elastin breakdown (yellow arrows in A) upon hsFLT1 (human sFLT1) overexpression (preeclampsia [PE]) compared with both controls (Ctrl/doxycycline [Dox] Ctrl). D, Periodic acid-Schiff reaction (PAS) and acid fuchsin-orange G (AFOG) stain of maternal kidneys (18.5 dpc) indicating glomerular endotheliosis upon hsFLT1 (PE); scale bar = 80 µm. E, Albumin/creatinine (mg/mg) ratio (18.5 dpc), was increased in PE dams compared with Ctrl. Data are presented as box plot with median, interquartile range±upper/lower extreme; sample size n is listed under each graph respectively; Kruskal-Wallis combined with Dunn multiple comparisons test; *P<0.05 and **P<0.01.