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. 2021 Sep 2;16(1):1286–1298. doi: 10.1515/med-2021-0335

Figure 5.

Figure 5

Effects of baicalin on the expressions of podocyte-related molecules and PI3K/Akt/mTOR signaling pathway in renal tissues of rats. The DN rats are administered with 50 mg/kg (Baicalin-L), 100 mg/kg (Baicalin-M), and 200 mg/kg (Baicalin-H) baicalin for 4 weeks by gavage, and their renal tissues are collected. (a) qRT-PCR to detect the mRNA expressions of Nephrin, Podocin, and Desmin in the renal tissues of rats in each group; (b) Western blot to detect the expressions of p-PI3K, PI3K, p-Akt, Akt, p-mTOR, and mTOR proteins in the renal tissues of rats in each group.## p < 0.01 vs Control group; *p < 0.05 and **p < 0.01 vs DN group.